反应详情

温度

120 °C

5-Bromo-2-methoxy-4-methylpyridine ([CAS Reg. No. 164513-39-7], 202 mg) was added to caesium carbonate (488 mg), 4-propionylpyridine ([CAS Reg. No. 1701-69-5], 165 mg) and chloro(di-2-norbornylphosphino)(2-dimethylaminomethylferrocen-1-yl)palladium (II), ([CAS Reg. No. 614753-51-4], 11 mg) in dioxane (2 ml). The mixture was heated in a sealed tube to 120° C. over night. Purification by preparative HPLC (Phenomenex Gemini Axia-C18 column, solvent gradient 20-95% CH3CN in 0.1% HCOOH[aq]) gave the title compound (30 mg). MS (m/e)=257.1 [M+H+].

1. customPurification by preparative HPLC (Phenomenex Gemini Axia-C18 column, solvent gradient 20-95% CH3CN in 0.1% HCOOH[aq])