Boron tribromide → HCID 57421308, compound

HRID 333851Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:33])[C:10]([C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[N:21]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[O:31]C)[N:20]=[CH:19]2)([OH:15])[C:11]([F:14])([F:13])[F:12].B(Br)(Br)Br>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:33])[C:10]([C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[N:21]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[OH:31])[N:20]=[CH:19]2)([OH:15])[C:11]([F:14])([F:13])[F:12]

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 57421307HCID 57421307, compound

Product 1

HCID 57421308HCID 57421308, compound

Procedure

In analogy to Example 183, 3-(2,4-dichloro-phenyl)-1,1,1-trifluoro-2-[1-(2-methoxy-phenyl)-1H-indazol-5-yl]-butan-2-ol (Example 189) was reacted with BBr3 to give the title compound as a colorless foam. MS (m/e, ISP neg. ion)=479.0 [M+H+].

Sources & evidence

ORD record: ord-4d44ff6587714b14bfaccd4880bc4ab8
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883786B2

Reaction notes

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