Boron tribromide → HCID 57421310, compound

HRID 333853Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:33])[C:10]([C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[N:21]([C:25]1[CH:30]=[CH:29][C:28]([O:31]C)=[CH:27][CH:26]=1)[N:20]=[CH:19]2)([OH:15])[C:11]([F:14])([F:13])[F:12].B(Br)(Br)Br>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:33])[C:10]([C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[N:21]([C:25]1[CH:26]=[CH:27][C:28]([OH:31])=[CH:29][CH:30]=1)[N:20]=[CH:19]2)([OH:15])[C:11]([F:14])([F:13])[F:12]

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 57421309HCID 57421309, compound

Product 1

HCID 57421310HCID 57421310, compound

Procedure

In analogy to Example 183, 3-(2,4-dichloro-phenyl)-1,1,1-trifluoro-2-[1-(4-methoxy-phenyl)-1H-indazol-5-yl]-butan-2-ol (Example 191) was reacted with BBr3 to give the title compound as a colorless foam. MS (m/e)=481.0 [M+H+].

Sources & evidence

ORD record: ord-bc05c120b7834247b59549413dba0133
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883786B2

Reaction notes

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