Boron tribromide → HCID 57421326, compound

HRID 333870Notes

Reaction equation

[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([O:9]C)[CH:5]=[CH:4][C:3]=1[CH:11]([CH3:26])[C:12]([C:18]1[CH:19]=[CH:20][C:21](=[O:25])[N:22]([CH3:24])[CH:23]=1)([OH:17])[C:13]([F:16])([F:15])[F:14].B(Br)(Br)Br>>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([OH:9])[CH:5]=[CH:4][C:3]=1[CH:11]([CH3:26])[C:12]([C:18]1[CH:19]=[CH:20][C:21](=[O:25])[N:22]([CH3:24])[CH:23]=1)([OH:17])[C:13]([F:16])([F:14])[F:15]

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 57421325HCID 57421325, compound

Product 1

HCID 57421326HCID 57421326, compound

Procedure

In analogy to Example 183, 5-[2-(2,3-dichloro-4-methoxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one (Example 208) was reacted with BBr3 to give the title compound as a light yellow foam. MS (m/e, ISP neg. ion)=393.8 [M−H+].

Sources & evidence

ORD record: ord-309ab5c74ea9448e83961bb432cbf231
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883786B2

Reaction notes

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