methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenylprop-1-ynyl)thiazole-4-carboxylate → methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenylpropyl)thiazole-4-carboxylate

Participants

Reaction Steps

To a solution of Example 15C (1.2 g) in ethyl acetate (120 mL) was added Pd/C (500 mg, 5%). The mixture was stirred under an atmosphere of hydrogen (balloon) overnight. The insoluble material was filtered off and washed with ethyl acetate. The filtrate was concentrated to provide the title compound.

Provenance & Evidence