反应详情

2,4-Dichloroquinoline (2.5 g, 12.6 mmol) was dissolved in anhydrous toluene (20 ml), a suspension of sodium methoxide (2.5 g, 46.3 mmol) in anhydrous toluene (20 ml) was added and the mixture was heated under reflux for 16 hours. After cooling to room temperature the suspension was filtered, the filter cake washed once with toluene (50 ml), the combined filtrates were evaporated under reduced pressure to dryness to yield 2.1 g (10.8 mmol, 86%) of a red solid. MS (ES) m/z=193.1 [M+H]+.

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureunder reflux for 16 hours
4. filtrationwas filtered
5. washthe filter cake washed once with toluene (50 ml)
6. customthe combined filtrates were evaporated under reduced pressure to dryness