反应详情

4-Chloro-2-methylquinoline (5 g, 28 mmol) was mixed with 1-methoxy-2-propanol, tert-butyl piperazine-1-carboxylate was added (5.74 g, 30.8 mmol) and the mixture was refluxed for 4.5 hours after which the product started to precipitate. The mixture was concentrated under reduced pressure and left at room temperature for 48 hours. The product was separated by filtration, washed with ethylacetate and dried at 50° C. 4.382 g of a solid were obtained (13.38 mmol, 48%). MS (APCI): m/z=327.9 [M+1]+.

1. additionwas added (5.74 g, 30.8 mmol)
2. temperaturethe mixture was refluxed for 4.5 hours after which the product
3. customto precipitate
4. concentrationThe mixture was concentrated under reduced pressure
5. customThe product was separated by filtration
6. washwashed with ethylacetate
7. customdried at 50° C