関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-(3-Methoxypropoxy)-1-propanol | HCID 66984 | — |
| 反応物 | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| 反応物 | 4-Chloro-2-methylquinoline | HCID 77973 | — |
| 生成物 | Ethyl 1-(2-methyl-4-quinolyl)piperidine-4-carboxylate | HCID 66835649 | 162.9% |
反応手順
4-Chloroquinaldine (0.888 g, 5 mmol) and ethyl piperidine-4-carboxylate (1.18 g, 7.5 mmol) were mixed together with dipropyleneglycolmonomethylether (5 ml) and stirred at 150° C. for 48 hours. The solvent was removed under reduced pressure and the residue purified by column chromatography (pre-packed silica column, gradient of dichloromethane/ethyl acetate) to give 2.43 g of a brown oil that was used directly in the next step. MS (APCI): m/z=298.9 [M+1]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08883791B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-6ddc65aa77e64eb28cd472ecbc1001f7 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
