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HRID333941

反应详情

EQUATION

反应方程式

HRID 333941 的结构方程式

REACTANTS

反应物

2
结构：Clc1ccnc2ccccc12
HCID69140

4-Chloroquinoline

C9H6ClN

结构：CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2
HCID11521263

(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE

C10H18N2O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2c1ccnc2ccccc12
HCID86691594

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：COCC(C)O
溶剂HCID7900

1-Methoxy-2-propanol

C4H10O2

CONDITIONS

反应条件

温度
115 °C

PROCEDURE

实验过程

4-Chloroquinoline (163.6 mg, 1 mmol) dissolved in 1-methoxy-2-propanol (4 ml) was added to tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (237 mg, 1.2 mmol) and stirred at 115° C. for 72 hours. The solvent was removed under reduced pressure and the residue obtained (325 mg) was used directly in the next step. MS (APCI) m/z=326.0 [M+H]+.

WORKUP

后处理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue obtained (325 mg)