Hydrochloric Acid → 4-[(1S,4S)-2,5-Diazabicyclo[2.2.1]heptan-5-yl]quinoline hydrochloride

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Reaction Steps

tert-Butyl (1S,4S)-5-(4-quinolyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (325 mg from step A) was dissolved in a 4M solution of HCl in anhydrous dioxane (4 ml) and stirred for one hour at room temperature. The volatiles were evaporated under reduced pressure, the residue was triturated two times with diethylether and the supernatant removed. The residue was dried in vacuo to obtain 317 mg of a solid. MS (APCI) m/z=225.9 [M+H]+.

Provenance & Evidence