HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 3-fluoro-N-methyl-2-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 1,3-Difluoro-2-nitrobenzene | HCID 87922 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-fluoro-N-methyl-2-nitroaniline | HCID 54489739 | — |
Reaction Steps
Reaction of 2.0 g (2.6 mmol) 2,6-difluoro-nitrobenzene with a 2 molar solution of methylamine in THF analogously to the process for preparing Intermediate 10a. Red solid. Yield: 1.8 g (86%); mass spectroscopy: [M+H]+=171.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429583B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-f358154421284c47883bfa1655f41a75 |
| Source note | uspto-grants-2008_09 |