反应详情

温度

140 °C

Ethyl 4,4,5,5,5-pentafluoro-3-hydroxy-pentanoate (11.9 g from step C) was placed in a 25 ml round-bottom flask and phosphorpentoxid was added in small portions until the educt was almost completely absorbed. The temperature was raised slowly to 140° C. until a brown syrup was obtained. The flask was connected to a distilling apparatus and the product isolated by distillation at reduced pressure (50 mbar, 50° C.). 5.5 g (25.2 mmol, 50% over 2 steps) were obtained which were used directly in the next step.

1. customwas almost completely absorbed
2. customwas obtained
3. customthe product isolated by distillation at reduced pressure (50 mbar, 50° C.)
4. custom5.5 g (25.2 mmol, 50% over 2 steps) were obtained which