反应详情

A solution of 2 g (6.7 mmol) 4-fluoro-1-methyl-3-(4-methyl-4-nitro-pentyl)-1,3-dihydro-benzimidazol-2-one in methanol is hydrogenated at 3 bar hydrogen pressure in the presence of Raney nickel. After separation of the catalyst hydrochloric acid in diethyl ether is added. The hydrochloride precipitated is filtered off and dried. Yield: 1.5 g (83%, hydrochloride); melting range=230-232° C.; mass spectroscopy: [M+H]+=303.

1. customAfter separation of the catalyst hydrochloric acid in diethyl ether
2. additionis added
3. customThe hydrochloride precipitated
4. filtrationis filtered off
5. customdried