Phosphorus oxide (P4O10) → Ethyl (E)-4,4,5,5-tetrafluoropent-2-enoate

Participants

Reaction Conditions

Reaction Steps

Ethyl 4,4,5,5-tetrafluoro-3-hydroxy-pentanoate (22.9 g, 0.105 mol) was mixed with phosphorus pentoxide (7.5 g, 0.053 mol) and the resulting mixture was stirred at 80° C. for two hours. The product was isolated by vacuum distillation (53 mbar, 92° C.) to yield 15.9 g of a liquid (0.08 mol, 76%) that was used directly in the next step.

Provenance & Evidence