Hydrazine hydrate (1:1) → HCID 86699358, compound

Participants

Reaction Conditions

Reaction Steps

278 mg of (R)-tert-butyl benzyl{2-(1,3-dioxoisoindolin-2-yl)propyl}carbamate was dissolved in 5 mL of methanol. To the solution, 1 mL of hydrazine hydrate was added, and the mixture was stirred at 80° C. for 12 hours. The reaction solution was cooled to room temperature and concentrated under reduced pressure. A 10% aqueous potassium hydroxide solution was added thereto, followed by extraction with dichloromethane (40 mL×3). The organic layer was washed with saturated saline and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (dichloromethane:methanol=2:1) to obtain 147 mg of the title compound as a colorless oil (79%).

Provenance & Evidence