HCID 86699362, compound → HCID 86699361, compound

Participants

Reaction Steps

2.85 g of (R)-benzyl 1-[tert-butoxycarbonyl{(S)-2-hydroxy-2-phenylethyl}amino]propan-2-ylcarbamate was dissolved in 40 mL of methanol. To the solution, 1.42 g of 20% palladium hydroxide-carbon was added, and the mixture was vigorously stirred at room temperature for 14 hours in a hydrogen gas atmosphere. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure. The obtained crude product was purified by silica gel column chromatography (dichloromethane:methanol=4:1) to obtain 1.86 g of the title compound as a colorless oil (96%).

Provenance & Evidence