Trifluoroacetic acid → HCID 86699363, compound

Participants

Reaction Steps

602 mg of tert-butyl (R)-1-[N—{(S)-2-hydroxy-2-(thiophen-3-yl)ethyl}-2-nitrophenylsulfonamido]propan-2-ylcarbamate was dissolved in 4 mL of dichloromethane. To the solution, 1 mL of trifluoroacetic acid was added, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure, and the residue was dissolved in 4 mL of methanol. 1 g of sodium bicarbonate was added thereto, and the mixture was stirred for 1 hour. After filtration, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (dichloromethane:methanol=8:1) to obtain 338 mg of the title compound as a colorless oil (71%).

Provenance & Evidence