HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(tert-butoxycarbonyl)glycine → HCID 89845514, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 57389812 | HCID 57389812 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 89845514 | HCID 89845514 | 151.3% |
Reaction Steps
A free form (220 mg) of the compound of Example 23 and N-(tert-butoxycarbonyl)glycine (25 mg) were condensed (230 mg, 73%) using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (137 mg) in dichloromethane. Subsequently, 100 mg of the title compound was obtained as a white solid (61%) from 150 mg of a free form according to the methods described in Steps 2 and 3 of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883792B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-a2e9b0bdefac4344bbad8c13498398f0 |
| Source note | uspto-grants-2014_11 |