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Triethylamine → (R)-N-(1-aminopropan-2-yl)isoquinoline-6-sulfonamide dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | tert-butyl N-((2R)-2-aminopropyl)carbamate | HCID 45072491 | — |
| 反応物 | Isoquinoline-6-sulfonyl chloride | HCID 55280287 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (R)-N-(1-aminopropan-2-yl)isoquinoline-6-sulfonamide dihydrochloride | HCID 86699367 | — |
反応手順
(R)-tert-butyl 2-aminopropylcarbamate (338 mg) synthesized according to the method described in PCT publication No. WO2010/006085 was condensed with isoquinoline-6-sulfonyl chloride prepared in Reference Example 1 in the presence of triethylamine (0.538 mL) in dichloromethane to obtain a crude product. Subsequently, 252 mg of the title compound was obtained as a white solid (38%) with reference to the methods of Steps 2 and 3 of Example 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08883792B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-82af080a607041e49c75d07010f4d384 |
| 出典メモ | uspto-grants-2014_11 |