HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetyl chloride → (R)-N-{2-(isoquinoline-6-sulfonamido)propyl}-2-phenylacetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetyl chloride | HCID 7679 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (R)-N-(1-aminopropan-2-yl)isoquinoline-6-sulfonamide dihydrochloride | HCID 86699367 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-N-{2-(isoquinoline-6-sulfonamido)propyl}-2-phenylacetamide hydrochloride | HCID 89845803 | 42.5% |
Reaction Steps
The compound of Example 102 (100 mg) and phenylacetyl chloride (45 mg) were condensed (72 mg, 63%) in the presence of triethylamine (0.123 mL) in dichloromethane. Subsequently, 52 mg of the title compound was obtained as a pale yellow solid (66%) with reference to the method of Step 3 of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883792B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-211bbddf5c08450cb402b8b0ee14f0c4 |
| Source note | uspto-grants-2014_11 |