3-Fluorophenylboronic acid → 1-(3-fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

HRID 334010Notes

Reaction equation

HRID 334010 reaction equation
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH:15]=[N:14][C:13]([C:16]([O:18]C)=[O:17])=[N:12]1.ClC1C=C(N2C=NC(C(O)=O)=N2)C=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([N:11]2[CH:15]=[N:14][C:13]([C:16]([OH:18])=[O:17])=[N:12]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 27339863-Fluorophenylboronic acidHCID 713019271-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acidHCID 178499122HCID 178499122, compound

Product 1

HCID 866882381-(3-fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

Procedure

This intermediate was prepared from 3-fluorophenylboronic acid and methyl 1,2,4-triazole-3-carboxylate in two steps according to the preparation of 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid.

Sources & evidence

ORD record
ord-f3c9626a89eb40a9ac583bcfa1cfbc2d
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

Loading…