2-Fluorophenylboronic acid → 1-(2-fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

HRID 334011Notes

Reaction equation

HRID 334011 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1B(O)O.[NH:11]1[CH:15]=[N:14][C:13]([C:16]([O:18]C)=[O:17])=[N:12]1.ClC1C=C(N2C=NC(C(O)=O)=N2)C=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:11]1[CH:15]=[N:14][C:13]([C:16]([OH:18])=[O:17])=[N:12]1

Participants

4

Reactant 3

HCID 27343542-Fluorophenylboronic acidHCID 713019271-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acidHCID 178499122HCID 178499122, compound

Product 1

HCID 713019111-(2-fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

Procedure

This intermediate was prepared from 2-fluorophenylboronic acid and methyl 1,2,4-triazole-3-carboxylate in two steps according to the preparation of 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid.

Sources & evidence

ORD record
ord-19329c17e19540d48afd71e2ae02c68d
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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