(2,5-Difluorophenyl)boronic acid → 1-(2,5-Difluoro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid

HRID 334012Notes

Reaction equation

HRID 334012 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1B(O)O.[NH:12]1[CH:16]=[N:15][C:14]([C:17]([O:19]C)=[O:18])=[N:13]1.ClC1C=C(N2C=NC(C(O)=O)=N2)C=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[N:12]1[CH:16]=[N:15][C:14]([C:17]([OH:19])=[O:18])=[N:13]1

Participants

4

Reactant 3

HCID 2734335(2,5-Difluorophenyl)boronic acidHCID 713019271-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acidHCID 178499122HCID 178499122, compound

Product 1

HCID 866882391-(2,5-Difluoro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid

Procedure

This intermediate was prepared from 2,5-difluorophenylboronic acid and methyl 1,2,4-triazole-3-carboxylate in two steps according to the preparation of 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid.

Sources & evidence

ORD record
ord-12c0d97a404647f18279f620e745a93f
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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