HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 4-(6-Cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 6-Cyclopropylpicolinic acid | HCID 82415191 | — |
| Reactant | 2,2-Dimethyl-piperazine-1-carboxylic acid benzyl ester trifluoroacetate | HCID 86688243 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(6-Cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester | HCID 86688244 | — |
Reaction Steps
200 mg (1.23 mmol) 6-cyclopropyl-pyridine-2-carboxylic acid was stirred with 450 mg (1.40 mmol) TBTU and 500 μL (2.91 mmol) DIPEA in 5.0 mL DMF at RT. After 10 min, 440 mg (1.23 mmol) 2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester trifluoroacetate was added and the reaction mixture was stirred at RT over night. Water was added and the product was extracted with EtOAc. The organic layers were dried over sodium sulfate and concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883789B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-92ce12ddab974b9ebbd9bffa03e183d8 |
| Source note | uspto-grants-2014_11 |