Benzoyl chloride, 3-chloro- → 4-(3-Chloro-benzoyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester

Participants

Reaction Steps

To a solution of 3.00 g (8.28 mmol) 2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester trifluoroacetate in 50 mL EtOAc was added 3.50 mL (20.3 mmol) DIPEA followed by 1.07 mL (8.28 mmol) 3-chloro-benzoyl chloride dropwise at RT. The reaction mixture was stirred at RT for 1 h. Then the suspension was washed with water. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo.

Provenance & Evidence