HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 334023Generated: October 30, 2026
Potassium Phosphate, Tribasic → 1-Cyclopropyl-isoquinoline-3-carboxylic acid methyl ester
https://huagongshe.com/reaction/334023
Participants
| Role | Name | HCID | Charge |
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| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Reactant | Methyl 1-chloroisoquinoline-3-carboxylate | HCID 15531562 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Cyclopropyl-isoquinoline-3-carboxylic acid methyl ester | HCID 86688254 | — |
Reaction Steps
A mixture of 481 mg (2.17 mmol) 1-chloro-isoquinoline-3-carboxylic acid methyl ester, 235 mg (2.74 mmol) cyclopropylboronic acid, 100 mg (0.137 mmol) 1,1′-bis(diphenyl-phosphino)ferrocenedichloropalladium(II) and 950 mg (4.47 mmol) potassium phosphate in 20 mL dioxane was stirred at 110° C. for 12 h. The mixture was diluted with EtOAc, filtered over Celite and activated carbon and concentrated in vacuo. The crude material was purified by flash chromatography (PE/EtOAc=3/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08883789B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-83cadb7270eb4b72a32808716d2d66cc |
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| Source note | uspto-grants-2014_11 |
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