反应详情

350 mg (1.54 mmol) 1-cyclopropyl-isoquinoline-3-carboxylic acid methyl ester was dissolved in 10 mL MeOH and treated with 2.50 mL 4 M aqueous NaOH solution at RT for 12 h. The solvent was removed by distillation, the residue taken up in water, acidified with 4 M aqueous hydrochlorid acid and extracted with EtOAc. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo.

1. customThe solvent was removed by distillation
2. extractionextracted with EtOAc
3. dry with materialThe combined organic phases were dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo