1-Boc-3,3-dimethylpiperazine → HCID 86688263, compound

HRID 334037Notes

Reaction equation

HRID 334037 reaction equation
[C:1]1([CH3:15])[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH:11]=[N:10][C:9]([C:12]([OH:14])=O)=[N:8]2)[CH:2]=1.C(OC([N:23]1[CH2:28][CH2:27][NH:26][C:25]([CH3:30])([CH3:29])[CH2:24]1)=O)(C)(C)C.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].CC1(C)CNCCN1C(C1N=CN(C2C=CC=CC=2)N=1)=O>>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[CH3:29][C:25]1([CH3:30])[CH2:24][NH:23][CH2:28][CH2:27][N:26]1[C:12]([C:9]1[N:10]=[CH:11][N:7]([C:3]2[CH:2]=[C:1]([CH3:15])[CH:6]=[CH:5][CH:4]=2)[N:8]=1)=[O:14]

Participants

4

Reactant 3

HCID 227103871-Boc-3,3-dimethylpiperazineHCID 713020901-(3-Methylphenyl)-1H-1,2,4-triazole-3-carboxylic acidHCID 86688259(2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]triazol-3-yl)-methanone trifluoroacetate

Product 1

HCID 86688263HCID 86688263, compound

Procedure

This intermediate was prepared from 1-m-tolyl-1H-[1,2,4]-triazole-3-carboxylic acid and 3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester in two steps according to the preparation of (2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate.

Sources & evidence

ORD record
ord-0a146e08f88b4394a9e426a0314a44e9
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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