1-Boc-3,3-dimethylpiperazine → HCID 86688265, compound

HRID 334038Notes

Reaction equation

HRID 334038 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[N:12][C:11]([C:14]([OH:16])=O)=[N:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8].C(OC([N:24]1[CH2:29][CH2:28][NH:27][C:26]([CH3:31])([CH3:30])[CH2:25]1)=O)(C)(C)C.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].CC1(C)CNCCN1C(C1N=CN(C2C=CC=CC=2)N=1)=O>>[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[CH3:30][C:26]1([CH3:31])[CH2:25][NH:24][CH2:29][CH2:28][N:27]1[C:14]([C:11]1[N:12]=[CH:13][N:9]([C:4]2[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([F:1])[CH:3]=2)[N:10]=1)=[O:16]

Participants

4

Reactant 3

HCID 227103871-Boc-3,3-dimethylpiperazineHCID 866882401-(3-Fluoro-4-methyl-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acidHCID 86688259(2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]triazol-3-yl)-methanone trifluoroacetate

Product 1

HCID 86688265HCID 86688265, compound

Procedure

This intermediate was prepared from 1-(3-fluoro-4-methyl-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid and 3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester in two steps according to the preparation of (2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate.

Sources & evidence

ORD record
ord-5046c1a9537246dfb882ed024af4d39f
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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