Sodium Hydroxide → 4-Bromo-6-methoxy-2-pyridinecarboxylic acid

HRID 334058Notes

Reaction equation

HRID 334058 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[C:9]([Br:11])[CH:8]=[C:7]([O:12][CH3:13])[N:6]=1)=[O:4].[OH-].[Na+]>CO>[Br:11][C:9]1[CH:8]=[C:7]([O:12][CH3:13])[N:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:10]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86688282HCID 86688282, compound

Product 1

HCID 155103794-Bromo-6-methoxy-2-pyridinecarboxylic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

246 mg (1.00 mmol) 4-bromo-6-methoxy-pyridine-2-carboxylic acid methyl ester was dissolved in 5 mL MeOH and treated with 2.50 mL 4 M aqueous NaOH solution at RT for 12 h. The solvent was removed by distillation. the residue was taken up in water and acidified with 4 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and dried.

Workup

  1. customThe solvent was removed by distillation
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-cb2239ce1f4c4526bc894a4439b55e38
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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