HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 334060Generated: October 30, 2026
Methanol → 3-chloro-6-fluoro-1-methoxyisoquinoline
https://huagongshe.com/reaction/334060
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 1,3-Dichloro-6-fluoroisoquinoline | HCID 46839960 | — |
| Product | 3-chloro-6-fluoro-1-methoxyisoquinoline | HCID 86688284 | — |
Reaction Steps
To a solution of 125 mg (3.00 mmol) sodium in 40 mL MeOH was added 668 mg (3.00 mmol) 1,3-dichloro-6-fluoro-isoquinoline. The reaction mixture was stirred at 70° C. for 30 min. The solvent was removed by distillation and the residue diluted with ice water. The precipitate was filtered off, washed with water and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08883789B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-c8d994cb1d8a44069c3b782386cadbb7 |
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| Source note | uspto-grants-2014_11 |
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