Sodium Hydroxide → HCID 84686425, compound

HRID 334061Notes

Reaction equation

HRID 334061 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[C:7]([O:16][CH3:17])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[CH:10][CH:9]=2)=[O:4].[OH-].[Na+]>CO>[F:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[C:7]([O:16][CH3:17])=[N:6][C:5]([C:3]([OH:4])=[O:2])=[CH:14]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86688285HCID 86688285, compound

Product 1

HCID 84686425HCID 84686425, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

690 mg (2.93 mmol) 6-fluoro-1-methoxy-isoquinoline-3-carboxylic acid methyl ester was dissolved in 20 mL MeOH and treated with 3.75 mL 4 M aqueous NaOH solution at RT for 3 h. The solvent was removed by distillation, the residue taken up in water and acidified with 4 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and purified by HPLC.

Workup

  1. customThe solvent was removed by distillation
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. custompurified by HPLC

Sources & evidence

ORD record
ord-b65673a816b8450f8966f7a36d0b14bf
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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