1,1'-Carbonyldiimidazole → HCID 86688291, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 394 mg (1.94 mmol) 6-bromo-pyridine-2-carboxylic acid in 30 mL THF was added 369 mg (2.28 mmol) 1,1′-carbonyldiimidazole. After stiffing at 60° C. for 4 h, 520 mg (1.63 mmol) [1-(3-chloro-phenyl)-1H-[1,2,4]triazol-3-yl]-(2,2-dimethyl-piperazin-1-yl)-methanone was added. The resulting mixture was stirred at 50° C. for 12 h. The solvent was evaporated. The residue was taken up in DMF and purified by HPLC.

Provenance & Evidence