HCID 86688291, compound → HCID 86688293, compound

HRID 334071Notes

Reaction equation

BrC1N=C(C(N2CCN(C(C3N=CN(C4C=CC=C(Cl)C=4)N=3)=O)C(C)(C)C2)=O)C=CC=1.[Cl:32][C:33]1[CH:34]=[C:35]([N:39]2[CH:43]=[N:42][C:41]([C:44]([N:46]3[CH2:51][CH2:50][N:49]([C:52]([C:54]4[CH:59]=[CH:58][CH:57]=[C:56]([C:60]5[CH2:61][CH2:62]O[CH2:64][CH:65]=5)[N:55]=4)=[O:53])[CH2:48][C:47]3([CH3:67])[CH3:66])=[O:45])=[N:40]2)[CH:36]=[CH:37][CH:38]=1>>[Cl:32][C:33]1[CH:34]=[C:35]([N:39]2[CH:43]=[N:42][C:41]([C:44]([N:46]3[CH2:51][CH2:50][N:49]([C:52]([C:54]4[CH:59]=[CH:58][CH:57]=[C:56]([C:60]5[CH2:61][CH2:62][CH2:64][CH:65]=5)[N:55]=4)=[O:53])[CH2:48][C:47]3([CH3:67])[CH3:66])=[O:45])=[N:40]2)[CH:36]=[CH:37][CH:38]=1

Participants

Reactant 2

HCID 86688291HCID 86688291, compound

HCID 86688292HCID 86688292, compound

Product 1

HCID 86688293HCID 86688293, compound

Procedure

This intermediate was prepared from [4-(6-bromo-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-chloro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone and cyclopenten-1-ylboronic acid ester according to the preparation of [1-(3-chloro-phenyl)-1H-[1,2,4]triazol-3-yl]-[4-[6-(3,6-dihydro-2H-pyran-4-yl)-pyridine-2-carbonyl]-2,2-dimethyl-piperazin-1-yl]-methanone.

Sources & evidence

ORD record: ord-eb5085b6a3c54ba7bd3182f1324efb5b
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883789B2

Reaction notes

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