[2,2-Dimethyl-4-(3-methylamino-4-nitro-benzoyl)-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]-triazol-3-yl)-methanone → [4-(4-Amino-3-methylamino-benzoyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]-triazol-3-yl)-methanone

Participants

Reaction Steps

A mixture of 445 mg (0.960 mmol) [2,2-dimethyl-4-(3-methylamino-4-nitro-benzoyl)-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]-triazol-3-yl)-methanone and 300 mg Raney nickel in 50 mL MeOH was hydrogenated at RT for 7.5 h. The catalyst was removed by filtration and the solvent was evaporated in vacuo.

Provenance & Evidence