HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylethyl (2S)-4-(phenylmethyl)-2-propyl-1-piperazinecarboxylate → tert-Butyl (2S)-2-propylpiperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylethyl (2S)-4-(phenylmethyl)-2-propyl-1-piperazinecarboxylate | HCID 86688297 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl (2S)-2-propylpiperazine-1-carboxylate | HCID 44593842 | — |
Reaction Steps
A mixture of 1.50 g (4.24 mmol; purity: 90%) (S)-4-benzyl-2-propyl-piperazine-1-carboxylic acid tert-butyl ester and 150 mg palladium on carbon in 30 mL methanol was hydrogenated at RT for 6 h at 3 bar. The catalyst was removed by filtration and the solvent was evaporated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883789B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-c76aa192aa334dedb7a115b994299ea4 |
| Source note | uspto-grants-2014_11 |