Diisopropylethylamine → 1,1-Dimethylethyl 3-methyl-4-[(1-phenyl-1H-1,2,4-triazol-3-yl)carbonyl]-1-piperazinecarboxylate

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Reaction Steps

To a mixture of 2.19 g (10.5 mmol) 3-methyl-piperazine-1-carboxylic acid tert-butyl ester and 2.50 mL (14.6 mmol) DIPEA in 15 mL DCM was added a solution of 2.18 g (10.5 mmol) 1-phenyl-1H-[1,2,4]-triazole-3-carbonyl chloride in 15 mL DCM. The reaction mixture was stirred at RT for 3 days, then washed with water. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo.

Provenance & Evidence