(4-Benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone → (3-Methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

HRID 334085Notes

Reaction equation

HRID 334085 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[N:17]=2)=[O:15])[CH2:10][C:9]1([CH2:25][O:26][CH3:27])[CH3:24])C1C=CC=CC=1>[Pd].CO>[CH3:27][O:26][CH2:25][C:9]1([CH3:24])[NH:8][CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[N:17]=2)=[O:15])[CH2:10]1

Participants

4

Reactant 1

HCID 86688307(4-Benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

Product 1

HCID 86688308(3-Methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 170 mg (414 μmol, purity: 90%) (4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone and 20 mg palladium on carbon in 10 mL methanol was hydrogenated at 50° C. for 12 h at 50 psi. The catalyst was removed by filtration and the solvent was evaporated in vacuo.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-1bd3ef443a624d2e966e9d99bac45393
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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