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Diisopropylethylamine → (S)-[4-(4,5-Dibromo-furan-2-carbonyl)-3-methyl-piperazin-1-yl]-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 反応物 | 4,5-Dibromofuran-2-carboxylic acid | HCID 4194832 | — |
| 反応物 | ((S)-3-methyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone | HCID 86688314 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (S)-[4-(4,5-Dibromo-furan-2-carbonyl)-3-methyl-piperazin-1-yl]-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone | HCID 86688313 | — |
反応手順
A mixture of 86 mg (0.30 mmol) ((S)-3-methyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone, 84 mg (0.30 mmol) 4,5-dibromo-2-furoic acid, 0.11 g (0.33 mmol) TBTU and 80 μL (0.45 mmol) DIPEA in 5.0 mL DMF was stirred at RT for 12 h. The reaction mixture was purified by HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08883789B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-d9c868ede75a4929872b8cfe3d67fe36 |
| 出典メモ | uspto-grants-2014_11 |