HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → {4-[1-(3-Chloro-phenyl)-1H-[1,2,4]triazole-3-carbonyl]-2,2-dimethyl-piperazin-1-yl}-(6-methoxy-pyridin-2-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid | HCID 71301927 | — |
| Reactant | (2,2-Dimethyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone trifluoroacetate | HCID 86688302 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | {4-[1-(3-Chloro-phenyl)-1H-[1,2,4]triazole-3-carbonyl]-2,2-dimethyl-piperazin-1-yl}-(6-methoxy-pyridin-2-yl)-methanone | HCID 86688317 | — |
Reaction Steps
A mixture of 50 mg (0.22 mmol) 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid, 80 mg (0.22 mmol) (2,2-dimethyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone trifluoroacetate, 77 mg (0.24 mmol) TBTU and 0.10 mL (0.58 mmol) DIPEA in 1.5 mL DMF was stirred at RT for 12 h. The reaction mixture was purified by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883789B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-84f2339868ee4ad289f2747736841ba8 |
| Source note | uspto-grants-2014_11 |