HCID 86688323, compound → HCID 71603633, compound

HRID 334098Notes

Reaction equation

HRID 334098 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([N:10]2[CH2:15][C:14]3([CH2:20][CH2:19]C[CH2:17][CH2:16]3)[N:13]([C:21]([C:23]3[N:27]=[CH:26][N:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[N:24]=3)=[O:22])[CH2:12][CH2:11]2)=[O:9])[CH:5]=[CH:6][CH:7]=1.FC(F)(F)C(O)=O.[Cl:41]C1C=C(C(N2CCNC(CC)(CC)C2)=O)C=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([N:10]2[CH2:11][CH2:12][N:13]([C:21]([C:23]3[N:27]=[CH:26][N:25]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([Cl:41])[CH:29]=4)[N:24]=3)=[O:22])[C:14]([CH2:16][CH3:17])([CH2:20][CH3:19])[CH2:15]2)=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 86688323HCID 86688323, compoundHCID 86688324HCID 86688324, compound

Product 1

HCID 71603633HCID 71603633, compound

Procedure

By using the same synthesis strategy as for (3-chloro-phenyl)-[1-(1-phenyl-1H-[1,2,4]-triazole-3-carbonyl)-1,4-diaza-spiro[5.5]undec-4-yl]-methanone the following compounds were prepared from (3-chloro-phenyl)-(3,3-diethyl-piperazin-1-yl)-methanone trifluoroacetate as amine and the respective carboxylic acid:

Sources & evidence

ORD record
ord-e3033fa240e648fdb6fe79b414611c26
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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