참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | Thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione | HCID 7059273 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 7-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dione | HCID 18326427 | 60% |
반응 단계
Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (10.38 g, 61.72 mmol) was dissolved in acetic acid (230 mL) and Bromine (11.13 mL, 216 mmol) was added. The reaction was heated at 80° C. for 3.5 h. Complete reaction was confirmed by LCMS. The reaction mixture was poured onto ice water slowly and filtered off the precipitate which was dried overnight under vacuum to give 7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (9.1 g, 60% yield)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08883799B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-2b62709c92634f6d93054bc037e3db69 |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
