HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 334188Generated: October 30, 2026
Potassium Carbonate → 1-[(3-Cyano-pyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromo-xanthine
https://huagongshe.com/reaction/334188
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione | HCID 21088927 | — |
| Reactant | 3-Pyridinecarbonitrile, 2-(chloromethyl)- | HCID 46911834 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-[(3-Cyano-pyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromo-xanthine | HCID 16726544 | — |
Reaction Steps
202 g (0.68 mol) of 3-methyl-7-(2-butin-1-yl)-8-bromoxanthine, 188.5 g (1.36 mol) of anhydrous potassium carbonate and 1.68 liters of N-methyl-2-pyrrolidone are initially charged in the reactor and heated to 70° C. Subsequently, 119 g (0.75 mol) of 2-chloromethyl-3-cyanopyridine in 240 ml of N-methyl-2-pyrrolidine (NMP) are added dropwise. The reactor contents are stirred at 70° C. for 19 hours. After the reaction has ended, 2.8 liters of water are added to the reaction mixture and it is cooled to 25° C. The product is filtered off, washed with 2 liters of water and dried at 70° C. in a drying cabinet under inertization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08883805B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-9e99d6afeca24ca68213790d433cb1ec |
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| Source note | uspto-grants-2014_11 |
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