HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1,1'-Biphenyl)-2-carboxaldehyde → 1-(Biphenyl-2-ylmethyl)-4-(2-ethoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1,1'-Biphenyl)-2-carboxaldehyde | HCID 121052 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-(2-Ethoxyphenyl)piperazine Hydrochloride | HCID 12862418 | — |
| Reactant | 1-(Biphenyl-2-ylmethyl)-4-phenylpiperazine | HCID 71602523 | — |
| Product | 1-(Biphenyl-2-ylmethyl)-4-(2-ethoxyphenyl)piperazine | HCID 71678171 | — |
Reaction Steps
112.3 mg of the target compound (0.30 mmol, 36.6%) was obtained using 1-(2-ethoxyphenyl)piperazine hydrochloride (400 mg, 1.65 mmol), biphenyl-2-carbaldehyde (150 mg, 0.82 mmol) and NaBH(OAc)3 (529 mg, 2.46 mmol) according to the synthesis method of Compound 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883796B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-0339e5edc4494554b271ac35726789ac |
| Source note | uspto-grants-2014_11 |