HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,4-Xylyl)piperazine → 1-(Biphenyl-2-ylmethyl)-4-(2,4-dimethylphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| Reactant | (1,1'-Biphenyl)-2-carboxaldehyde | HCID 121052 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-(Biphenyl-2-ylmethyl)-4-phenylpiperazine | HCID 71602523 | — |
| Product | 1-(Biphenyl-2-ylmethyl)-4-(2,4-dimethylphenyl)piperazine | HCID 71602642 | — |
Reaction Steps
201.6 mg of the target compound (0.57 mmol, 69.0%) was obtained using 1-(2,4-dimethylphenyl)piperazine (312 mg, 1.64 mmol), biphenyl-2-carbaldehyde (150 mg, 0.82 mmol) and NaBH(OAc)3 (529 mg, 2.46 mmol) according to the synthesis method of Compound 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883796B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-32ccbbe1bb704f5eb502340b1cb11392 |
| Source note | uspto-grants-2014_11 |