HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Methoxyphenyl)piperazine → 1-(4'-Chlorobiphenyl-2-ylmethyl)-4-(2-methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Methoxyphenyl)piperazine | HCID 1346 | — |
| Reactant | 4'-Chlorobiphenyl-2-carbaldehyde | HCID 1393689 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-(Biphenyl-2-ylmethyl)-4-phenylpiperazine | HCID 71602523 | — |
| Product | 1-(4'-Chlorobiphenyl-2-ylmethyl)-4-(2-methoxyphenyl)piperazine | HCID 71602690 | — |
Reaction Steps
215 mg of the target compound (0.55 mmol, 42.4%) was obtained using 1-(2-methoxyphenyl)piperazine (497 mg, 2.58 mmol), 4′-chlorobiphenyl-2-carbaldehyde (280 mg, 1.29 mmol) and NaBH(OAc)3 (832 mg, 3.87 mmol) according to the synthesis method of Compound 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883796B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-df5479a52bb240b4b13fcdb2e3a5ec5f |
| Source note | uspto-grants-2014_11 |