Hydrochloric Acid → HCID 56848597, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol (542 mg, 0.729 mmol) in dioxane (4 mL) was added HCl (4 N, aq, 4 mL) at rt. The resulting mixture was stirred at 40° C. for 1 h. The reaction mixture was evaporated to dryness to afford 4-(7-amino-6-bromo-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol as a gray solid (296 mg), which was used without further purification. HPLC-MS TR=1.08 min (UV 254 nm, 3 min method); mass calculated for formula C22H23BrN6O2 482.1, observed LCMS m/z 483.1 (M+H).

Provenance & Evidence