Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3,5-Difluoroaniline | HCID 96595 | — |
| Reactant | 6-Chloro-3-nitropyridine-2-carbonitrile | HCID 13381705 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 68276419 | HCID 68276419 | 33% |
Reaction Steps
A mixture of 6.5 g of 6-chloro-3-nitropicolinonitrile (0.065 mol) and 6.2 g of 3,5-difluoroaniline (0.048 mol) in 100 ml of toluene is heated at 70° C. for 5 hours. The crude reaction product is diluted in an ethyl acetate fraction and washed using saturated NaCl solution. The organic phase is dried with sodium sulfate and the residue purified by silica gel chromatography (AcOEt/petroleum ether) to yield 3.9 g (33%) of a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08883821B2 |
|---|
| Source dataset | uspto-grants-2014_11 |
|---|
| ORD ID | ord-c49b0a5bfbf54c61b6fa84d40390f063 |
|---|
| Source note | uspto-grants-2014_11 |
|---|
