HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 3-Cyano-5-(3,5-difluorobenzyloxy)pyridine 1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 5-(3,5-Difluorobenzyloxy)nicotinonitrile | HCID 68276533 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-Cyano-5-(3,5-difluorobenzyloxy)pyridine 1-oxide | HCID 68276442 | 75.1% |
Reaction Steps
224 mg of m-CPBA is added at 0° C. to a solution in acetonitrile of 250 mg of 5-(3,5-difluorobenzyloxy)nicotinonitrile. The reaction medium is stirred for 20 hours while a precipitate is formed progressivelt. This solid is then filtered and washed to yield 200 mg (75%) of 3-cyano-5-(3,5-difluorobenzyloxy)pyridine 1-oxide in the form of a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883821B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-d0087d435e954b02b0173f4f2eee3ac3 |
| Source note | uspto-grants-2014_11 |