HCID 68276402, compound → HCID 68276494, compound

HRID 334428Notes

Reaction equation

HRID 334428 reaction equation
[I-].[C:2]([O:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][N+:18]([CH3:21])=[CH:17][CH:16]=2)=[CH:11][C:10]=1[N+:22]([O-])=O)=[O:8])([CH3:5])([CH3:4])[CH3:3].[H][H]>CO>[NH2:22][C:10]1[CH:11]=[C:12]([CH:15]2[CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH2:20]2)[CH:13]=[CH:14][C:9]=1[C:7]([O:6][C:2]([CH3:3])([CH3:4])[CH3:5])=[O:8]

Participants

4

Reactant 2

HCID 68276402HCID 68276402, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68276494HCID 68276494, compoundYield 140.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.48 g of platine (IV) oxide (2.12 mmol) is added to a solution of 26.8 g of 4-(4-(tert-butoxycarbonyl)-3-nitrophenyl)-1-methylpyridinium iodide (60.6 mmol) in 200 mL of methanol placed in a reactor made in stainless steel. The reaction medium is brought under 5 bar of hydrogen for 24 h. The catalyst is filtered and the filtrate is concentrated under reduced pressure to yield 24.8 g (98%) of white crystals.

Workup

  1. customplaced in a reactor
  2. filtrationThe catalyst is filtered
  3. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-46351b2f657b4693ad260c8acdb7dd79
Source dataset
uspto-grants-2014_11
Patent number
US08883821B2

Reaction notes

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